Definition

A protein made from pieces of two genes that get joined together. The BCR-ABL fusion protein is found in most people with chronic myelogenous leukemia, and in some people with acute lymphoblastic leukemia or acute myelogenous leukemia. Inside the leukemia cells, the ABL gene from chromosome 9 joins to the BCR gene on chromosome 22 to form the BCR-ABL fusion gene, which makes the BCR-ABL fusion protein. Also called BCR::ABL fusion protein.