Definition

A serious condition that occurs when there is an extremely low number of granulocytes (a type of white blood cell) in the blood. Granulocytes are an important part of the immune system and help the body fight infection. Having very low levels of granulocytes in the blood can lead to serious or life-threatening infections. Signs and symptoms of agranulocytosis include fever, chills, weakness, sore throat, sores in the mouth or throat, bleeding gums, bone pain, low blood pressure, fast heartbeat, and trouble breathing. Agranulocytosis may be inherited or caused by certain autoimmune or bone marrow disorders, infection, poor nutrition, cancer treatment (such as chemotherapy or bone marrow transplant), or exposure to certain toxins, chemicals, or medicines.