Single Biggest Cancer Dictionary in the World

What is

WT1/PSMA/hTERT-encoding plasmid DNA INO-5401

?

Pronunciation: /wt* wən psma* htert* ɛnˈkoʊdɪŋ plasmid* ˈdiˌɛˈneɪ ino* faɪv ˈθaʊzənd, fɔr ˈhənərd ənd wən/

WT1/PSMA/hTERT-encoding plasmid DNA INO-5401

Definition

A preparation composed of three separate DNA plasmids encoding the tumor-associated antigens (TAAs) Wilms tumor gene-1 (WT1), prostate-specific membrane antigen (PSMA) and human telomerase reverse transcriptase (hTERT), with potential immunostimulating and antineoplastic activites. Upon intramuscular delivery and electroporation of the WT1/PSMA/hTERT-encoding plasmid DNA INO-5401, the genes are translated into their respective proteins inside the cell. The expressed proteins activate the immune system and induce a cytotoxic T-lymphocyte (CTL)-mediated response against cells expressing the WT1, PSMA and hTERT antigens, causing tumor cell lysis. hTERT, WT1 and PSMA are upregulated in many cancer cell types.