Definition

A transcription factor (TF) protein, with potential antineoplastic activity. Upon administration, TF protein SON-DP induces pluripotent reprogramming in cancer cells and generates transient induced pluripotent stem cells (tiPSCs). The in situ generated tiPSCs quickly re-differentiate into normal tissue cells. The tiPSCs also secrete exosomes, which provides embryonic stem cells (ESC)-like microenvironments. This may result in malignant phenotype reversion in the surrounding cancer cells. In addition, the tiPSCs may revert distant metastatic cancer cells into normal cells through tropism effect.