Single Biggest Cancer Dictionary in the World
What is
TORC1/2 kinase inhibitor DS-3078a
?Pronunciation: /torc* wən tu kinase* ˌɪnˈhɪbətər ds* θri ˈθaʊzənd ənd seventy-eight* ə/
TORC1/2 kinase inhibitor DS-3078a
Definition
An orally bioavailable inhibitor of raptor-mTOR protein complex (TORC1) and rictor-mTOR protein complex (TORC2) with potential antineoplastic activity. TORC1/2 inhibitor DS-3078a binds to and inhibits both TORC1 and TORC2 , which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.