Single Biggest Cancer Dictionary in the World
What is
topoisomerase I inhibitor LMP776
?Pronunciation: /topoisomerase* aɪ ˌɪnˈhɪbətər lmp* ˈsɛvən ˈhənərd ənd seventy-six*/
topoisomerase I inhibitor LMP776
Definition
An indenoisoquinoline and non-camptothecin inhibitor of topoisomerase I (Top I) with potential antineoplastic activity. Topoisomerase I inhibitor LMP776 binds to the topoisomerase I-DNA covalent cleavage complexes, and inhibits repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. Compared to camptothecins, indenoisoquinolines are chemically stable, produce stable Top I-DNA cleavage complexes, induce unique DNA cleavage sites and appear more resistant to multidrug efflux pumps.