Single Biggest Cancer Dictionary in the World

What is

topical gemcitabine hydrochloride

?

Pronunciation: /ˈtɑpɪkəl gemcitabine* hydrochloride*/

topical gemcitabine hydrochloride

Definition

A topical preparation of gemcitabine hydrochloride with antineoplastic activity. Gemcitabine, an analogue of the antimetabolite nucleoside deoxycytidine, is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.