Single Biggest Cancer Dictionary in the World

What is

thyrointegrin alphaVbeta3 antagonist fb-PMT

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Pronunciation: /thyrointegrin* alphavbeta* θri ænˈtægənəst fb* pmt*/

thyrointegrin alphaVbeta3 antagonist fb-PMT

Definition

A fluorobenzyl polyethylene glycol (PEG) conjugated to tetraiodothyroacetic acid that targets the thyrointegrin alphaVbeta3, with potential antineoplastic activity. Upon administration, the thyrointegrin alphaVbeta3 antagonist fb-PMT targets and binds to alphaVbeta3 integrin. This results in the inhibition of angiogenesis and metastasis. The mechanism of actions (MOAs) through which fb-PMT exerts its actions may be more complex and may be through multiple signaling pathways. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is overexpressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types.