Single Biggest Cancer Dictionary in the World
What is thorium Th 227 anti-PSMA monoclonal antibody BAY 2315497?
Pronunciation: /ˈθɑriəm ˈtiˈeɪʧ tu ˈhənərd ənd twenty-seven* ˈænˌti psma* ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi beɪ tu ˈmɪljən, θri ˈhənərd ənd ˈfɪfˈtin ˈθaʊzənd, fɔr ˈhənərd ənd ninety-seven*/
thorium Th 227 anti-PSMA monoclonal antibody BAY 2315497
Definition
A radioimmunoconjugate consisting of a monoclonal antibody targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and labeled, via a 3-hydroxypyridin-2-one (3,2-HOPO) chelator, with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of BAY 2315497 targets and specifically binds to PSMA on tumor cells, delivering a cytotoxic dose of alpha radiation to cells expressing PSMA. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.