Single Biggest Cancer Dictionary in the World
What is thalicarpine?
Pronunciation: /thalicarpine*/
thalicarpine
Definition
A natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle.