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What is
temanogrel hydrochloride
?Pronunciation: /temanogrel* hydrochloride*/
temanogrel hydrochloride
Definition
The hydrochloride salt form of temanogrel, an orally bioavailable, selective inverse agonist of 5-hydroxytryptamine receptor 2A (5-HT2A), with potential anti-thrombotic and vasodilating activities. Upon oral administration, temanogrel targets, binds to and inhibits 5-HT2A expressed on platelet surfaces and in smooth muscle cells, thereby inhibiting 5-HT-mediated platelet aggregation and vasoconstriction. This may attenuate platelet aggregation and vasoconstriction, and improve blood flow.