Single Biggest Cancer Dictionary in the World
What is
technetium Tc 99m methylene diphosphonate
?Pronunciation: /technetium* tc* ninety-nine* ɛm ˈmɛθɪˌlin diphosphonate*/
technetium Tc 99m methylene diphosphonate
Definition
A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scinitgraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions.