Single Biggest Cancer Dictionary in the World
What is
TCR-specific, alpha fetoprotein-enhanced autologous T lymphocytes
?Pronunciation: /tcr* spɪˈsɪfɪk ˈælfə fetoprotein* ɛnˈhænst autologous* ti ˈlɪmfəˌsaɪts/
TCR-specific, alpha fetoprotein-enhanced autologous T lymphocytes
Definition
A preparation of human autologous T lymphocytes transduced with a viral vector encoding for a T-cell receptor (TCR) specific for human alpha-fetoprotein (AFP), with potential antineoplastic activity. Following administration, the TCR-specific, alpha fetoprotein-enhanced autologous T lymphocytes recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers.