Definition

A vaccine comprised of a synthetic modified Vaccinia virus Ankara (sMVA) viral vector encoding the two severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) surface antigens spike (S) and nucleocapsid (N) proteins, with potential immunizing activity against SARS-CoV-2. Upon administration of the sMVA-based SARS-CoV-2 vaccine COH04S1, the SARS-CoV-2 S and N proteins are expressed in cells and presented to the immune system. This may activate both humoral and cellular immune responses which may result in protection against SARS-CoV-2 infection.