Single Biggest Cancer Dictionary in the World
What is
selective estrogen receptor covalent antagonist TQB3915
?Pronunciation: /səˈlɛktɪv ˈɛstrəʤən riˈsɛptər covalent* ænˈtægənəst tqb* θri ˈθaʊzənd, naɪn ˈhənərd ənd ˈfɪfˈtin/
selective estrogen receptor covalent antagonist TQB3915
Definition
An orally bioavailable, selective and covalent antagonist of estrogen receptor alpha (ERalpha; ERa; ESR1; nuclear receptor subfamily 3, group A, member 1; NR3A1), with potential antineoplastic activity. Upon oral administration, selective estrogen receptor covalent antagonist TQB3915 selectively and covalently binds to and inhibits the activity of ERalpha. This inhibits the growth and survival of ERalpha-expressing cancer cells. ERalpha, a nuclear hormone receptor often overexpressed and/or mutated in a variety of cancer cell types, plays a key role in tumor cell proliferation and survival.