Definition

A genetically modified strain of Salmonella enterica, serotype typhimurium that expresses L-methioninase, with potential antineoplastic activity. Upon administration, Salmonella enterica serotype typhimurium expressing L-methioninase SGN1 selectively accumulates and replicates in tumor cells, inhibiting the growth of tumors. SGN1 also delivers the oncolytic enzyme L-methioninase, a pyridoxal phosphate-dependent enzyme that catalyzes the elimination of L-methionine, to tumor cells. This eliminates L-methionine and results in cell-cycle arrest at the S/G2 phase and tumor cell death. Most tumors are methionine-dependent for growth and proliferation.