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What is RIP1 inhibitor GDC-8264?
Pronunciation: /rɪp wən ˌɪnˈhɪbətər gdc* eɪt ˈθaʊzənd, tu ˈhənərd ənd sixty-four*/
RIP1 inhibitor GDC-8264
Definition
An orally available inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1; receptor-interacting protein 1; RIP1) with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, RIP1 inhibitor GDC-8264 inhibits RIP1-mediated signaling, which may preserve intestinal stem cells (ISCs) and prevent RIP1-mediated gastrointestinal (GI) damage in acute graft-versus-host disease (GvHD). RIP1 plays a key role in inflammation and cell death in response to tissue damage and pathogen recognition.