Single Biggest Cancer Dictionary in the World

What is

recombinant human endostatin

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Pronunciation: /rɪˈkɑmbɪnənt ˈjumən endostatin*/

recombinant human endostatin

Definition

A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction in tumor burden. This agent also may decrease hepatic metastasis by inhibiting proinflammatory cytokines and vascular cell adhesion molecule (VCAM)-dependent cell attachment to the hepatic microvasculature.