Definition

A recombinant fusion protein composed of human serum albumin (HSA) fused to human granulocyte colony stimulating factor (G-CSF), with potential granulopoietic activity. Upon administration, recombinant HSA/G-CSF fusion protein MW05 mimics endogenous G-CSF that is produced by monocytes, fibroblasts, and endothelial cells. G-CSF binds to and activates specific cell surface receptors, thereby stimulating the proliferation, differentiation, function, and survival of neutrophil precursors and mature neutrophils. This may prevent granulocytopenia. HSA fusion increases the molecular weight of G-CSF, prolongs its half-life and masks G-CSF, thereby preventing G-CSF degradation which further increases the half-life and bioavailability of G-CSF.