Definition

An orally bioavailable pan-mutant and wild-type Ras inhibitor, with potential antineoplastic activity. Upon oral administration, Ras inhibitor RSC-1255 selectively targets, binds to and inhibits both wild-type and mutated forms of Ras, thereby inhibiting Ras-dependent signaling and inhibits proliferation of tumor cells in which Ras is overexpressed and/or mutated. Ras serves an important role in cell signaling, division and differentiation. Mutations of Ras may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.