Single Biggest Cancer Dictionary in the World
What is Raf kinase inhibitor XL281?
Pronunciation: /ræf kinase* ˌɪnˈhɪbətər xl* tu ˈhənərd ənd eighty-one*/
Raf kinase inhibitor XL281
Definition
An orally active, small molecule with potential antineoplastic activity. XL281 specifically inhibits RAF kinases, located downstream from RAS in the RAS/RAF/MEK/ERK kinase signaling pathway, which may result in reduced proliferation of tumor cells. RAS mutations may result in constitutive activation of the RAS/RAF/MEK/ERK kinase signaling pathway, and have been found to occur frequently in human tumors.