Definition

A supplement composed of R-1,3-butanediol that may be used to increase the level of the ketone body beta-hydroxybutyrate (BHB), with potential protective and antineoplastic activities. Upon administration of R-1,3-butanediol-based supplement, R-1,3-butanediol is converted to BHB. BHB may activate the surface receptor hydroxycarboxylic acid receptor 2 (HCAR2) and induce the transcriptional regulator homeodomain-only protein (HOPX), thereby inhibiting cell proliferation in intestinal epithelial cells that express HCAR2 and HOPX.