Single Biggest Cancer Dictionary in the World

What is PSA/PSMA/PSCA-encoding DNA plasmid vaccine PF-06755990?

Pronunciation: /psa* psma* psca* ɛnˈkoʊdɪŋ ˈdiˌɛˈneɪ plasmid* ˌvækˈsin pf* sɪks ˈmɪljən, ˈsɛvən ˈhənərd ənd fifty-five* ˈθaʊzənd, naɪn ˈhənərd ənd ˈnaɪnti/

PSA/PSMA/PSCA-encoding DNA plasmid vaccine PF-06755990

Definition

A DNA vaccine consisting of plasmids encoding the tumor-associated antigens (TAAs) human prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) and prostate stem cell antigen (PSCA), with potential immunostimulating and antineoplastic activities. Upon administration via intramuscular electroporation, the PSA/PSMA/PSCA-encoding DNA Plasmid Vaccine PF-06755990 expresses PSA, PSMA and PSCA, which may elicit a cytotoxic T-lymphocyte (CTL) response against tumor cells that are expressing PSA, PSMA and PSCA, resulting in tumor cell lysis. PSA, PSMA and PSCA are overexpressed on a variety of cancer cell types.