Single Biggest Cancer Dictionary in the World
What is pixantrone dimaleate?
Pronunciation: /pixantrone* dimaleate*/
pixantrone dimaleate
Definition
The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.