Single Biggest Cancer Dictionary in the World
What is PI3Ka/mTOR inhibitor PKI-179?
Pronunciation: /paɪ θri kɑ mtor* ˌɪnˈhɪbətər pki* wən ˈhənərd ənd seventy-nine*/
PI3Ka/mTOR inhibitor PKI-179
Definition
A second generation, small-molecule mimetic of ATP that targets the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. PKI-179 selectively inhibits mTOR and phosphoinositide-3-kinase (PI3K) alpha. By inhibiting the PI3K/mTOR signaling pathway, this agent may inhibit tumor cell proliferation and survival.