Single Biggest Cancer Dictionary in the World
What is PAK4 inhibitor PF-03758309?
Pronunciation: /pæk fɔr ˌɪnˈhɪbətər pf* θri ˈmɪljən, ˈsɛvən ˈhənərd ənd fifty-eight* ˈθaʊzənd, θri ˈhənərd ənd naɪn/
PAK4 inhibitor PF-03758309
Definition
An orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.