Single Biggest Cancer Dictionary in the World
What is p-cadherin antagonist PF-03732010?
Pronunciation: /pi cadherin* ænˈtægənəst pf* θri ˈmɪljən, ˈsɛvən ˈhənərd ənd thirty-two* ˈθaʊzənd ənd tɛn/
p-cadherin antagonist PF-03732010
Definition
An agent that inhibits p-cadherin (cdh3), with potential antineoplastic activity. PF-03732010 binds to and inhibits the activity of p-cadherin. Inhibition of the activity of p-cadherin may inhibit tumor cell invasion and proliferation in p-cadherin expressing tumor cells. P-cadherin, a cell-surface protein and member of the cadherin family, is overexpressed in a variety of solid tumors, and plays a role in cell adhesion, motility, invasion and proliferation.