Definition

A recombinant form of oncolytic vesicular stomatitis virus (VSV), with potential immunomodulating and antineoplastic activities. Upon administration, oncolytic VSV preferentially replicates in tumor cells. This induces VSV-mediated cytolytic activity towards the tumor cells. VSV, a single-stranded RNA virus belonging to the genus Vesiculovirus of the family Rhabdoviridae, is relatively nonpathogenic to healthy humans but is able to rapidly replicate in and induce apoptosis of tumor cells.