Definition

An antineoplastic agent targeting mutant forms of nuclear factor erythroid 2-related factor 2 protein (NFE2L2), Kelch-like ECH-associated protein 1 (KEAP1), and Cullin-3 (CUL3), with potential antineoplastic activity. Upon administration, NFE2L2/KEAP1/CUL3 mutant-targeting agent MGY825 inhibits the activity of NFE2L2, KEAP1 and CUL3 mutant forms, thereby halting the proliferation of NFE2L2, KEAP1, and CUL3 mutant-expressing tumor cells. NFE2L2/KEAP1/CUL3 are mutated in certain tumor cell types.