Definition

A peptide-based cancer vaccine consisting of patient-specific antigens, which are immunogenic and unique to the patient’s tumor, with potential immunomodulating and antineoplastic activities. Upon vaccination with the neoantigen peptide vaccine, the peptides stimulate the host immune system to mount a specific cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, which results in tumor cell lysis.