Single Biggest Cancer Dictionary in the World
What is multi-epitope anti-folate receptor peptide vaccine TPIV 200?
Pronunciation: /ˈməlti ˈɛpɪˌtoʊp ˈænˌti folate* riˈsɛptər ˈpɛpˌtaɪd ˌvækˈsin tpiv* tu ˈhənərd/
multi-epitope anti-folate receptor peptide vaccine TPIV 200
Definition
A peptide vaccine containing five immunogenic peptide epitopes of the human folate receptor 1 (FOLR1; FR-alpha), with potential immunomodulating and antineoplastic activities. Upon intradermal administration, multi-epitope anti-folate receptor peptide vaccine TPIV 200 may induce a cytotoxic T-lymphocyte (CTL) response against FR-alpha-overexpressing tumor cells. FR-alpha is a high-affinity folate-binding protein and a member of the folate receptor family; this receptor is overexpressed in various cancer cell types.