Definition

A human non-fucosylated immunoglobulin G1 (IgG1) monoclonal antibody directed against an as of yet undisclosed cell surface receptor expressed on cytotoxic cells, with potential immunomodulatory and antineoplastic activities. Upon administration, monoclonal antibody DR-01 binds to the as of yet undisclosed cell surface receptor expressed on cytotoxic cells and induce antibody-dependent cellular cytotoxicity (ADCC) against these cytotoxic cells. This may reduce tumor cell proliferation of certain leukemias and lymphomas, and modulate immune responses in certain autoimmune conditions.