Single Biggest Cancer Dictionary in the World

What is mitomycin?

Pronunciation: /mitomycin*/

mitomycin

Definition

A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin also inhibits RNA and protein synthesis at high concentrations.