Definition

An orally bioavailable, cultivated microbiome therapeutic composed of a consortium of fermented bacterial species that were specifically selected to decrease infection and translocation of antibiotic-resistant bacteria in the gastrointestinal (GI) tract, with potential immunomodulating activity. Upon oral administration, microbiome SER-155 may restore the unhealthy, altered gut microbiome, enhance the microbial diversity and function in the GI tact and may re-establish a healthy microbiome in the GI tract. This may enhance the patients’ immunological activity and lower the risk of GI antibiotic-resistant bacterial infections, bacteremia and graft-versus-host disease (GvHD) in patients undergoing solid organ and allogeneic stem cell transplantation.