Single Biggest Cancer Dictionary in the World
What is MET tyrosine kinase inhibitor SAR125844?
Pronunciation: /mɛt tyrosine* kinase* ˌɪnˈhɪbətər sɑr wən ˈhənərd ənd tˈwɛntiˌfaɪv ˈθaʊzənd, eɪt ˈhənərd ənd forty-four*/
MET tyrosine kinase inhibitor SAR125844
Definition
An inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of cancers, plays an important role in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis.