Definition

A preparation of tumor-infiltrating lymphocytes (TILs) that have been genetically engineered to express membrane-bound IL-15 (mbIL15), with potential immunostimulating and antineoplastic activities. Upon introduction of the mbIL15-expressing TILs OBX-115, the TILs target and kill tumor cells. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells. Sustained IL-15 signaling enhances TIL persistence and potency compared to un-engineered TILs. OBX-115 may replace the need for concomitant administration of systemic IL-2 which is needed to improve the efficacy of conventional TILs.