Single Biggest Cancer Dictionary in the World

What is

lutetium Lu 177 rsopatamab tetraxetan

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Pronunciation: /lutetium* lu wən ˈhənərd ənd seventy-seven* rsopatamab* tetraxetan*/

lutetium Lu 177 rsopatamab tetraxetan

Definition

A radioimmunoconjugate consisting of rosopatamab, a humanized monoclonal antibody (MoAb) against the external domain of the prostate-specific membrane antigen (PSMA) that is linked, via the chelating agent, dodecanetetraacetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity and imaging activity during single-photon emission computerized tomography/computerized tomography (SPECT/CT). Upon administration, lutetium Lu 177 rosopatamab tetraxetan binds to PSMA expressed on certain tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to PSMA-expressing cells. PSMA is overexpressed in the malignant prostate and its metastases.