Single Biggest Cancer Dictionary in the World
What is KW-2149?
Pronunciation: /kw* tu ˈθaʊzənd, wən ˈhənərd ənd forty-nine*/
KW-2149
Definition
A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis.