Single Biggest Cancer Dictionary in the World
What is KAT6 inhibitor PF-07248144?
Pronunciation: /kæt sɪks ˌɪnˈhɪbətər pf* ˈsɛvən ˈmɪljən, tu ˈhənərd ənd forty-eight* ˈθaʊzənd, wən ˈhənərd ənd forty-four*/
KAT6 inhibitor PF-07248144
Definition
An inhibitor of MYST histone acetyltransferase (HAT) KAT6, with potential antineoplastic activity. Upon administration, KAT6 inhibitor PF-07248144 targets and binds to KAT6, and inhibits the acetylation of histones and other nonhistone substrates. This may disrupt gene expression and inhibit the proliferation of tumors that overexpress KAT6. KAT6A (MOZ; MYST3) and KAT6B (MORF; MOZ2; MYST4), commonly amplified genes in solid tumors, play key roles in cell cycle regulation and in tumorigenesis.