Definition

A radioimmunoconjugate composed of vofatamab, a human immunoglobulin G1 (IgG1) monoclonal antibody directed against the fibroblast growth factor receptor type 3 (FGFR3) labeled, via a bifunctional chelate, with the radioisotope indium In 111, with potential use as an imaging agent upon single photon emission computed tomography/computed tomography (SPECT/CT). Upon administration of Indium In 111 vofatamab, the vofatamab moiety specifically targets and binds to FGFR3. Upon SPECT/CT imaging, FGFR3-expressing tumor cells can be visualized. FGFR3, a receptor tyrosine kinase upregulated or mutated in many tumor cell types, plays a key role in tumor cell proliferation.