Definition

A radioimmunoconjugate containing the recombinant immunoglobulin G1 (IgG1) kappa humanized monoclonal antibody h11B6 that targets human kallikrein-2 (HK2) conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the radioisotope indium In 111, with potential use as an imaging agent. Upon administration of indium In 111-DOTA-h11B6, the h11B6 moiety targets and binds to HK2. Upon binding and radioimaging, HK2-expressing tumor cells can be visualized and the binding of h11B6 can be assessed. HK2 is overexpressed on a variety of cancer cells.