Single Biggest Cancer Dictionary in the World
What is indium In-111-DOTA-di-HSG peptide IMP-288?
Pronunciation: /ˈɪndiəm ɪn wən ˈhənərd ənd ˈilɛvən dota* di hsg* ˈpɛpˌtaɪd ɪmp tu ˈhənərd ənd eighty-eight*/
indium In-111-DOTA-di-HSG peptide IMP-288
Definition
A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide indium (In) 111. After pretargeting with a bispecific monoclonal antibody (BiMoAB) directed against both a tumor associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of administered indium-In-labeled di-HSG-DOTA peptide IMP-288 binds the anti-HSG portion of the BiMoAB; In-111 radioisotopic activity localized to tumor cells bearing the TAA can then be visualized scintigraphically.