Single Biggest Cancer Dictionary in the World

What is

GNAQ/GNA11 antagonist DYP688

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Pronunciation: /gnaq* gna* ˈilɛvən ænˈtægənəst dyp* sɪks ˈhənərd ənd eighty-eight*/

GNAQ/GNA11 antagonist DYP688

Definition

An antagonist of guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)/ guanine nucleotide-binding protein subunit alpha-11 (GNA11), with potential antineoplastic activity. Upon administration, GNAQ/GNA11 antagonist DYP688 inhibits the activity of GNAQ/GNA11 and prevents GNAQ/GNA11-mediated signaling. This may prevent proliferation in tumors overexpressing and/or harboring mutations of GNAQ/GNA11. GNAQ and GNA11 are involved in carcinogenesis and are mutated in certain melanomas.