Single Biggest Cancer Dictionary in the World
What is
GNAQ/GNA11 antagonist DYP688
?Pronunciation: /gnaq* gna* ˈilɛvən ænˈtægənəst dyp* sɪks ˈhənərd ənd eighty-eight*/
GNAQ/GNA11 antagonist DYP688
Definition
An antagonist of guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)/ guanine nucleotide-binding protein subunit alpha-11 (GNA11), with potential antineoplastic activity. Upon administration, GNAQ/GNA11 antagonist DYP688 inhibits the activity of GNAQ/GNA11 and prevents GNAQ/GNA11-mediated signaling. This may prevent proliferation in tumors overexpressing and/or harboring mutations of GNAQ/GNA11. GNAQ and GNA11 are involved in carcinogenesis and are mutated in certain melanomas.