Definition

A radioconjugate composed of NY104, a small molecule carbonic anhydrase IX (CAIX; carbonic anhydrase 9; CA9; G250)-targeting tracer comprised of an acetazolamide core, a hydrophilic spacer and the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N’,N”-triacetic acid (NOTA), labeled with the radionuclide gallium Ga 68, with potential use as a tracer for CAIX-expressing tumor cells during positron emission tomography (PET). Upon administration of gallium Ga 68 NY104, the NY104 moiety targets and binds to CAIX-expressing tumor cells. Upon binding, CAIX-expressing tumor cells can be detected during PET. CAIX, a member of the carbonic anhydrase family and a tumor-associated antigen (TAA), is found in a majority of renal cell carcinomas while absent in most normal tissues.