Definition

A radioconjugate composed of a nectin-4 (poliovirus receptor-like 4; PVRL4)-targeting moiety, labeled with gallium Ga 68, with potential nectin-4 imaging activity during positron emission topography (PET)/computed tomography (CT). After intravenous administration of gallium Ga 68 N188, the nectin-4-targeting moiety selectively targets and binds to nectin-4 expressed on tumor cells. Upon PET/CT imaging, nectin-4-expressing tumor cells can be visualized. Nectin-4, a tumor-associated antigen (TAA) belonging to the nectin family, is overexpressed in a variety of cancers, but has a restricted distribution in normal tissue.