Definition

A sulfamoylanthranilic acid derivative and loop diuretic, with potential antiviral activity. Upon topical administration, furosemide gel inhibits potassium influx by interacting with cell membrane ion co-transporter, Na+-K+-2Cl-co-transporter-1(NKCC1; SLC12A2). This may inhibit potassium influx and prevent the replication of DNA viruses, such as human papillomavirus (HPV), that rely on potassium for replication.