Definition

A radiotracer composed of the adnectin BMS-986192, a fibronectin-based protein that targets programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), labeled with the radioisotope fluorine F 18, with potential use for assessing PD-L1 tumor antigen expression using positron emission tomography (PET). Upon administration of fluorine F 18 BMS-986192, the BMS-986192 moiety specifically targets and binds to PD-L1 expressed on certain tumor cells. Upon PET imaging, the radiotracer can be visualized and the extent of PD-L1 expression can be assessed. Adnectins, a protein family derived from the 10th type III domain of human fibronectin with high-affinity targeting capabilities, have favorable physicochemical properties, such as small size, high stability, high affinity and specificity.