Definition

A radioconjugate composed of the human prostate-specific membrane antigen (PSMA)-targeting ligand, florastamin, labeled with the radioisotope fluorine F 18, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 florastamin, the florastamin moiety targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells can be detected during PET/CT imaging. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.