Single Biggest Cancer Dictionary in the World

What is

fluorine F 18 dasatinib

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Pronunciation: /ˈflʊˌrin ɛf ˈeɪˈtin dasatinib*/

fluorine F 18 dasatinib

Definition

A radioconjugate composed of a derivative of the multi-targeted kinase inhibitor dasatinib conjugated to the radioisotope fluorine F 18, with potential imaging activity during positron emission tomography (PET). Upon administration of fluorine F 18 dasatinib, dasatinib targets and binds to Bcr/Abl, SRC-family protein-tyrosine kinases, c-Kit and platelet-derived growth factor receptor (PDGFR). Upon binding, the fluorine F 18 moiety allows PET imaging of tumor cells and can be used as a tracer for the biodistribution of dasatinib.