Definition

A radioconjugate composed of a myeloperoxidase (MPO) activity tracer labeled with fluorine F 18, with potential use for imaging of MPO activity and areas of inflammation using positron emission tomography (PET). Upon administration of fluorine F 18 4-fluoro-1-naphthol, the 4-fluoro-1-naphthol moiety selectively binds to nearby proteins and cells when they are oxidized by MPO plus hydrogen peroxide, but not hydrogen peroxide alone. This allows the visualization of MPO activity using PET. MPO is one of the key effector molecules and enzymes of innate immunity.